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Capreomycin sulfate from Streptomyces capreolus

SIGMA/C4142 - antibacterial peptide

CAS Number: 1405-37-4
EC Number: 215-776-8
MDL Number: MFCD00079032
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-C4142-1G 1 g
$323.00
1/EA
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45-C4142-5G 5 g
$632.00
1/EA
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C4142-1G

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
  mycobacteria
form powder
InChI 1S/C24H42N14O8.H2O4S/c25-4-1-2-10(26)17(40)32-7-13-19(42)34-14(8-33-24(29)46)20(43)38-16(12-3-5-30-23(28)37-12)22(45)31-6-11(27)18(41)36-15(9-39)21(44)35-13;1-5(2,3)4/h8,10-13,15-16,39H,1-7,9,25-27H2,(H,31,45)(H,32,40)(H,34,42)(H,35,44)(H,36,41)(H,38,43)(H3,28,30,37)(H3,29,33,46);(H2,1,2,3,4)/b14-8-;/t10-,11+,12?,13+,15-,16-;/m0./s1
InChI key LFFNIXQXRKNZCE-UBBQZPMLSA-N
mode of action DNA synthesis | interferes
Quality Level 200 
SMILES string OS(O)(=O)=O.NCCC[C@H](N)C(=O)NC[C@H]1NC(=O)[C@H](CO)NC(=O)[C@H](N)CNC(=O)[C@@H](NC(=O)C(NC1=O)=CNC(N)=O)[C@H]2CCNC(=N)N2
storage temp. −20°C
Application: Capreomycin is used to study bacterial ribosomal subunit interactions and translocation processes during protein synthesis. It is a second line antibiotic and is used to study multidrug-resistant tuberculosis.
Biochem/physiol Actions: Capreomycin is a cyclic peptide antibiotic that is often grouped with aminoglycosides. It binds across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix 44 (h44).
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
Packaging: 1, 5 g in glass bottle
Preparation Note: Sparingly soluble in water.
Storage Temp. −20°C
UNSPSC 51281628

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