Cyclopamine hydrate

SIGMA/C4116 - ≥98% (HPLC)

Synonym: 11-deoxojervine hydrate

CAS Number: 1217465-07-0
Empirical Formula (Hill Notation): C₂₇H₄₁NO₂ · xH₂O
Molecular Weight: 411.62 (anhydrous basis)
Linear Formula: C₂₇H₄₁NO₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C4116-1MG	1 mg	$282.00 1/EA		Add To Favorites
45-C4116-5MG	5 mg	$1240.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	solid
InChI	1S/C27H41NO2.H2O/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2;/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3;1H2/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-;/m0./s1
InChI key	KDAGJRDPNXDDSB-HBYCUIHISA-N
Quality Level	100
SMILES string	O.C[C@@H]1CN[C@H]2[C@@H](C)[C@@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)O[C@@H]2C1
solubility	DMSO: soluble ≥5 mg/mL
	H₂O: insoluble
storage temp.	2-8°C

Application:	Cyclopamine hydrate has been used: • as a sonic hedgehog (Shh) inhibitor in various experiments • to explore the effects of stress stimulation on the proliferation and differentiation of fibrochondrocytes • to study its influence on ocular vessel patterning
Biochem/physiol Actions:	Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.
Features and Benefits:	This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	Cyclopamine is a steroidal alkaloid, extracted from Veratrum californicum. It prevents tumor cell growth and invasiveness in vitro and in vivo.
Packaging:	1, 5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352116

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