8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt

SIGMA/C3912 - ≥97.0% (HPLC), powder

Synonym: pCPT-cAMP

CAS Number: 93882-12-3
Empirical Formula (Hill Notation): C₁₆H₁₄ClN₅NaO₆PS
Molecular Weight: 493.79
EC Number: 299-413-9
MDL Number: MFCD00057683
Linear Formula: C₁₆H₁₄ClN₅NaO₆PS
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C3912-10MG	10 mg	$94.80 1/EA	Add To Favorites
45-C3912-50MG	50 mg	$276.00 1/EA	Add To Favorites
45-C3912-100MG	100 mg	$472.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C3912-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97.0% (HPLC)
color	white
form	powder
InChI	1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-;/m1./s1
InChI key	YIJFVHMIFGLKQL-DNBRLMRSSA-M
Quality Level	200
SMILES string	[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12
solubility	H₂O: 25 mg/mL
storage temp.	−20°C

Application:	8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt has been used: • to upregulate cellular cholesterol pump (adenosine triphosphate- (ATP-) binding cassette (ABC) transporter-1, ABCA-1) • in glucose production assay • to stimulate cystic fibrosis transmembrane conductance regulator (CFTR) channel in airway epithelia
Biochem/physiol Actions:	Membrane permeable cAMP analog. Used as a selective activator of cAMP dependent protein kinase (PKA). Inhibits cGMP-dependent phosphodiesterase and, at higher concentrations, inhibits cAMP-dependent phosphodiesterase. Inhibits phosphoinositide hydrolysis and secretion stimulated by n-formyl-Met-Leu-Phe but not platelet-activating factor in leukocytes. Renders HL-60 cells more resistant to NO-induced DNA damage.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	10 mg in glass bottle
Packaging:	50, 100 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97.0% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

To Order From a Quote