CI 976
SIGMA/C3743 - >98% (HPLC), solid
Synonym: 2,2-
CAS Number: 114289-47-3
Empirical Formula (Hill Notation): C23H39NO4
Molecular Weight: 393.56
MDL Number: MFCD00869662
Linear Formula: C23H39NO4
Product Type: Chemical
| assay | >98% (HPLC) |
| form | solid |
| InChI | 1S/C23H39NO4/c1-7-8-9-10- |
| InChI key | WAFNZAURAWBNDZ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CCCCCCCCCCC(C)(C)C(=O)Nc1 |
| solubility | DMSO: >10 mg/mL |
| H2O: insoluble <2 mg/mL | |
| storage temp. | 2-8°C |
| Application: | CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor: • to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells • to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs) • to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells |
| Biochem/physiol Actions: | CI-976 is a potent and specific inhibitor of liver and intestinal acyl coenzyme A:cholesterol acyltransferase (ACAT) in vitro. |
| Biochem/physiol Actions: | CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol. |
| Packaging: | 5 mg in glass bottle |
| Hazard statements | H413 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 51111800 |