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Cetirizine dihydrochloride

SIGMA/C3618 - ≥98% (HPLC)

Synonym: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

CAS Number: 83881-52-1
Empirical Formula (Hill Notation): C21H25ClN2O3 · 2HCl
Molecular Weight: 461.81
MDL Number: MFCD00941428
Linear Formula: C21H25ClN2O3 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C3618-50MG 50 mg
 $56.80
1/EA		 Add To Favorites
45-C3618-250MG 250 mg
 $258.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
InChI key PGLIUCLTXOYQMV-UHFFFAOYSA-N
Quality Level 100 
relevant disease(s) allergies
SMILES string OC(COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1)=O.[H]Cl.[H]Cl
solubility H2O: 5 mg/mL, clear
storage condition desiccated
Application: Cetirizine dihydrochloride has been used as an antagonist for histamine receptors H1 in HSDSEAP (poly) clonal cells derived from human embryonic kidney HEK-293 cells. It has also been used as a ligand in the crystallization of equine serum albumin cetirizine complex.
Biochem/physiol Actions: Cetirizine hydrochloride is a non-sedating type histamine H1-receptor antagonist.
Biochem/physiol Actions: Cetirizine hydrochloride is an orally active and selective H1-receptor antagonist. Antihistaminic; Piperazines. Non-sedating type histamine H1-receptor antagonist; major metabolite of hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer.
Biochem/physiol Actions: Cetirizine is a racemic mixture of (R)-levocetirizine and (S)-dextrocetirizine. It exists as a zwitterion at acidic pH and gets absorbed by passive diffusion. Cetirizine is a prescribed drug for allergic rhinitis and chronic idiopathic urticaria.
Features and Benefits: This compound is a featured product for ADME Tox research. Click here  to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Histamine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 50, 250 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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