Coenzyme A trilithium salt

SIGMA/C3019 - ≥93%

Synonym: CoA Li₃

CAS Number: 18439-24-2
Empirical Formula (Hill Notation): C₂₁H₃₃Li₃N₇O₁₆P₃S
Molecular Weight: 785.33
EC Number: 242-317-9
MDL Number: MFCD00075848
Linear Formula: C₂₁H₃₃Li₃N₇O₁₆P₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C3019-10MG	10 mg	$87.80 1/EA	Add To Favorites
45-C3019-25MG	25 mg	$157.00 1/EA	Add To Favorites
45-C3019-100MG	100 mg	$379.00 1/EA	Add To Favorites
45-C3019-500MG	500 mg	$2050.00 1/EA	Add To Favorites
45-C3019-1G	1 g	$3720.00 1/EA	Add To Favorites

Coenzyme A (CoA, CoASH or HSCoA) is the key cofactor in first step of the TCA cycle, responsible for transferring the acetyl group from pyruvate oxidation to oxaloacetate yielding citrate. Coenzyme A is also a critical cofactor in fatty acid metabolism. Coenzyme A carries fatty acids through the catabolic/oxidation process in the mitochondria and transfers acetyl groups during the elongation process of fatty acid synthesis in the cytosol.

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C3019-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥93%
form	powder
InChI	1S/C21H36N7O16P3S.3Li/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);;;/q;3*+1/p-3/t11-,14-,15-,16?,20-;;;/m1.../s1
InChI key	QSCBPHBAFBVXRK-HJKJOZROSA-K
Quality Level	200
SMILES string	[Li+].[Li+].[Li+].CC(C)(COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
storage temp.	−20°C

Application:	Coenzyme A trilithium salt has been used: • in standard curve generation in the kinetic assay of acetyltransferase Gcn5 acylation • as a cofactor in JNADH and JNADPH production assay • in the labeling of Alexa647 (AF647) probe
Biochem/physiol Actions:	Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. Acyl CoA accumulation is implicated in metabolic disorders and may indirectly lead to the pathogenesis associated with carbon-induced mitochondrial stress heart failure, diabetes and obesity.
General description:	Coenzyme A (CoA) is synthesized from phosphopantothenate by the action of enzyme pantothenate kinase and is the master regulator.
Other Notes:	For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource .
Packaging:	1 g in poly bottle
Packaging:	10, 25, 100, 500 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥93%
Storage Temp.	−20°C
UNSPSC	41106305

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