Complement C7 from human serum
SIGMA/C2787 - ≥85% (SDS-PAGE), ≥150,000 C7H50 units/mg protein
CAS Number: 80295-57-4
MDL Number: MFCD00130845
Product Type: Chemical
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| assay | ≥85% (SDS-PAGE) |
| biological source | human serum |
| concentration | 1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2 |
| form | solution |
| Quality Level | 200  |
| shipped in | dry ice |
| specific activity | ≥150,000 C7H50 units/mg protein |
| storage temp. | −70°C |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P10643  |
| Analysis Note: | Functionally active by a sensitive hemolytic assay. |
| Biochem/physiol Actions: | The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis. A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell. Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis. |
| Disclaimer: | RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥85% (SDS-PAGE) |
| activity | specific activity: ≥150,000 C7H50 units/mg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352205 |