CX546

SIGMA/C271 - ≥98% (HPLC), solid

Synonym: 1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine

CAS Number: 215923-54-9
Empirical Formula (Hill Notation): C₁₄H₁₇NO₃
Molecular Weight: 247.29
MDL Number: MFCD01860868
Linear Formula: C₁₄H₁₇NO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C271-10MG	10 mg	$306.00 1/EA		Add To Favorites
45-C271-50MG	50 mg	$1090.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	solid
InChI	1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
InChI key	LJUNPHMOGNFFOS-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C(N1CCCCC1)c2ccc3OCCOc3c2
solubility	DMSO: ≥10 mg/mL
storage condition	protect from light
storage temp.	2-8°C

Application:	CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.
Biochem/physiol Actions:	CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.
Biochem/physiol Actions:	Positive AMPA glutamate receptor modulator.
Disclaimer:	Photosensitive
General description:	CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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