Anti-Calcium Channel CaV3.1 (α1G) antibody produced in rabbit
SIGMA/C2240 - affinity isolated antibody, lyophilized powder
MDL Number: MFCD04975325
Product Type: Chemical
Immunohistochemistry Anti-Cav3.1: Cat. No. C2240: Immunohistochemical staining of Rat cerebellum using Anti-Cav3.1 antibody. A. Cav3.1 immunoreactivity (green) appears in the molecular layer. B. Nuclear staining using DAPI as the counterstain (blue). C. Merged images A and B. Mol = molecular layer.
Immunoblotting Anti-Cav3.1: Cat. No. C2240: Western blot analysis of Rat brain membranes. Lanes 1. Anti-Cav3.1 antibody, (1:200). 2. Anti-Cav3.1 antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:200 using rat brain membranes |
| UniProt accession no. | O54898  |
| Application: | Anti-Calcium Channel CaV3.1 (α1G) antibody produced in rabbit is suitable for western blotting at a dilution of 1:200 using rat brain membranes. |
| Biochem/physiol Actions: | CACNA1G (T-type channels) are involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance and rebound burst firing. It exhibits a significant window current that helps for Fe2+ pathway entry into cells with relevant concentrations of extracellular Fe2+. The window current also creates a pathway for Cd2+ entry into cells during Cd2+ exposure. CACNA1G were found to be associated with Autism Spectrum Disorder. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Calcium channel, voltage-dependent, T type, α 1G subunit is a protein encoded by CACNA1G gene in humans. It belongs to a family of voltage-gated calcium channels and serves as the key transducer of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events. |
| Immunogen: | peptide corresponding to amino acid residues 1-22 of rat CaV3.1. This epitope is highly homologous in human (20/22 residues identical). |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |