Synonym: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt; 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt
CAS Number: 148819-94-7
Empirical Formula (Hill Notation): C14H16KN2O4
Molecular Weight: 315.39
MDL Number: MFCD00216153
Linear Formula: C14H16KN2O4
Product Type: Chemical
| assay |
≥98% (TLC) |
| biological source |
synthetic (organic) |
| form |
powder |
| InChI |
1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1 |
| InChI key |
VYEUQMVIGXFZQU-UHFFFAOYSA-M |
| mp |
>270 °C |
| Quality Level |
100  |
| SMILES string |
[K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C |
| solubility |
DMSO: soluble (lit.)(lit.) |
| |
H2O: 100 mg/mL |
| |
methanol: soluble (lit.)(lit.) |
| storage temp. |
2-8°C |
| Application: |
Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4) |
| Biochem/physiol Actions: |
Carboxy-PTIO can make a quick reaction with nitric oxide (NO) to produce nitrogen dioxide (NO2). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO. |
| Biochem/physiol Actions: |
Reacts with nitric oxide to form carboxy-PTI derivatives which in turn inhibits nitric oxide synthase. |
| General description: |
2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO) is mainly considered as a scavenger of nitric oxide (NO). |
| Packaging: |
10 mg in glass insert |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (TLC) |
| mp |
>270 °C |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
