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Corticosterone: HBC complex

SIGMA/C174 - free flowing powder

CAS Number: 50-22-6
MDL Number: MFCD00163376
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C174-100MG 100 mg
 $192.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C174-100MG

 

assay ≥91.5% (HPLC)
biological source synthetic (organic)
form free flowing powder
InChI 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Quality Level 100 
shipped in ambient
SMILES string O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C
sterility non-sterile
storage temp. room temp
Application: Corticosterone: HBC complex has been used:
• in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
• to induce acute stress in mice
•  in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription
Biochem/physiol Actions: The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule. Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.
Other Notes: Preformed water-soluble complex of corticosterone and 2-hydroxypropyl-β-cyclodextrin. Package size is total weight of both the corticosterone and the 2-hydroxypropyl-β-cyclodextrin. Corticosterone content: 66.7 mg/g
Packaging: 100 mg in glass bottle
Preparation Note: Corticosterone content: 66.7 mg/g. When 1 g of complex is reconstituted with water to a total volume of 2.12 mL, a solution which is 90.8 mM in corticosterone is obtained. Corticosterone itself is virtually insoluble in water.
Purity ≥91.5% (HPLC)
Storage Temp. room temp
UNSPSC 51111800

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