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Cibenzoline succinate

SIGMA/C1618 - ≥98% (HPLC), solid

Synonym: 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate; Cibenol; Cipralan; Exacor

CAS Number: 100678-32-8
Empirical Formula (Hill Notation): C18H18N2 ·C4H6O4
Molecular Weight: 380.44
MDL Number: MFCD00941423
Linear Formula: C18H18N2 ·C4H6O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C1618-10MG 10 mg
 $212.00
1/EA		 Add To Favorites
45-C1618-50MG 50 mg
 $634.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to brown
form solid
InChI 1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8)
InChI key XFUIOIWYMHEPIE-UHFFFAOYSA-N
Quality Level 100 
SMILES string OC(=O)CCC(O)=O.C1CN=C(N1)C2CC2(c3ccccc3)c4ccccc4
solubility H2O: ≥5 mg/mL
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.
Biochem/physiol Actions: Cibenzoline succinate inhibits ATP-sensitive K+ channels; class IA antiarrhythmic.
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(−) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient.
Packaging: 10, 50 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P264 - P270 - P301 + P312 - P501
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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