Carmofur
SIGMA/C1494 - ≥98% (HPLC), powder
Synonym: 1-
CAS Number: 61422-45-5
Empirical Formula (Hill Notation): C11H16FN3O3
Molecular Weight: 257.26
MDL Number: MFCD00866284
Linear Formula: C11H16FN3O3
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts C1494-50MG
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C11H16FN3O3/c1-2-3-4-5 |
| InChI key | AOCCBINRVIKJHY-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CCCCCCNC(=O)N1C=C(F)C(=O) |
| solubility | DMSO: >15 mg/mL |
| storage temp. | 2-8°C |
| Application: | Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine . |
| Biochem/physiol Actions: | Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (Mpro) in vitro. |
| Biochem/physiol Actions: | Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent. |
| Biochem/physiol Actions: | Carmofur is an antineoplastic agent and a flurorouracil analog. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301 - H361 |
| Precautionary statements | P201 - P301 + P310 + P330 |
| Hazard Codes | T |
| Risk Statements | 60-61-25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |