Cilnidipine

SIGMA/C1493 - ≥98% (HPLC), powder

Synonym: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester; FRC 8653

CAS Number: 132203-70-4
Empirical Formula (Hill Notation): C₂₇H₂₈N₂O₇
Molecular Weight: 492.52
MDL Number: MFCD00865853
Linear Formula: C₂₇H₂₈N₂O₇
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C1493-10MG	10 mg	$191.00 1/EA	Add To Favorites
45-C1493-50MG	50 mg	$763.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	light yellow
form	powder
InChI	1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
InChI key	KJEBULYHNRNJTE-DHZHZOJOSA-N
Quality Level	100
SMILES string	COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OCC=Cc3ccccc3
solubility	DMSO: ≥20 mg/mL
	H₂O: ≤2 mg/mL
storage condition	protect from light

Application:	Cilnidipine has been used: • in cell viability assay of pheochromocytoma (nPC12) cells • in photoirradiation and photodegradation studies • to understand effect on albuminuria in diabetic nephropathy
Biochem/physiol Actions:	A slow-acting Ca²⁺ channel blocker, antihypertensive; vasodilator.
Biochem/physiol Actions:	Cilnidipine is a slow-acting Ca²⁺ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca²⁺ channels in vascular smooth muscle and N-type Ca²⁺channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.
Features and Benefits:	This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	10, 50 mg in glass bottle
Packaging:	Protect from high temperatures.

Symbol	GHS05
Signal word	Danger
Hazard statements	H318
Precautionary statements	P280 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	41
Safety Statements	26-39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
UNSPSC	12352200

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