Curcumin
SIGMA/C1386 - from Curcuma longa (Turmeric), powder
Synonym: (E,E)
CAS Number: 458-37-7
Empirical Formula (Hill Notation): C21H20O6
Molecular Weight: 368.38
EC Number: 207-280-5
MDL Number: MFCD00008365
Linear Formula: [HOC6H3(OCH3)CH=CHCO]2CH2
Product Type: Chemical
ATR-IR Spectra for (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C1386-50G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C1386-10G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C1386-5G
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| biological source | Curcuma longa (Turmeric) |
| concentration | ≥65% (HPLC) |
| form | powder |
| InChI | 1S/C21H20O6/c1-26-20-11-1 |
| InChI key | VFLDPWHFBUODDF-FCXRPNKRSA |
| mp | 175 °C |
| Quality Level | 200  |
| SMILES string | COc1cc(C=CC(=O)CC(=O)C |
| solubility | 0.5 M NaOH: soluble (then immediately dilute in PBS [lit.])(lit.) |
| DMSO: >11 mg/mL (lit.)(lit.) | |
| ethanol: 10 mg/mL | |
| storage temp. | −20°C |
| vapor density | 13 (vs air) |
| Application: | Curcumin has been used: • to study its effect on the consequences and mechanism involved in the suppression of human homeobox gene NKX3.1 in the prostate cancer cell LNCaP • to examine its effect on stress in pigs by having an inhibitory impact on the serum cortisol concentration, hippocampal nitric oxide production, and brain-derived neurotrophic factor expression • to study its effect as a dietary supplement on the growth, immunity, antioxidant activity, and disease resistance in Oreochromis niloticus • to analyze its protective effect on the organotypic hippocampal slice cultures against the synaptic toxicity caused by amyloid beta peptides (Aβ1–42) • to examine the possibility of its non-toxic concentrations to decrease the inflammation caused by interleukin-1beta (IL-1β) in cartilage explant cultures • to study its protective impact against intestinal ischemia-reperfusion injury in rats • to measure its antibacterial activity in vitro • to determine its preventative effects for Alzheimer′s disease (AD) in mice • as a bifunctional agent for generation and validation of the erythroid 2-related factor 2 (Nrf2) reporter system • to study its in vitro inhibitory effects on human liver glucuronidation activity • to evaluate its effects on Parkinson′s disease (PD)-like phenotypes |
| Biochem/physiol Actions: | A natural phenolic compound responsible for the yellow color of turmeric. Potent anti-tumor agent that acts against highly diverse tumor-specific pathways. Anti-inflammatory and anti-oxidant. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX). |
| Biochem/physiol Actions: | A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. |
| Biochem/physiol Actions: | Curcumin possesses anti-inflammatory, cancer prophylactic, and anti-oxidant properties. It also exhibits antagonistic nature towards the cluster of colon, breast, and blood marrow cancer. It does so by means of having an inhibitory effect on the various associated enzymes such as cycloxygenase-2 (COX-2), lipoxygenase and ornithine decarboxylase. It is also postulated to have anti-depressant, anti-stress and neuroprotective effects on humans and other animals. It is being proclaimed to be used as a treatment for Alzheimer′s disease due to its ability to cause synaptic toxicity. Additionally, it also shows anti-fungal, antiviral, anti-microbial, chemosensitizing, radiosensitizing, and wound healing activities. |
| Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| General description: | Curcumin is a yellow-colored polyphenol obtained from the rhizome of Curcuma longa L. It constitutes an important part of various diets and herbal medicines, especially in the Asian continent for its various salubrious effects on human health. |
| Other Notes: | 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research  |
| Packaging: | 5, 10, 50 g in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 175 °C |
| Storage Temp. | −20°C |
| Colour Index Number | 75300 |
| UNSPSC | 12352205 |