Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

SIGMA/C1230 - ≥90% (TLC), powder

Synonym: Z-IETD-FMK

CAS Number: 220760-26-9
Empirical Formula (Hill Notation): C₃₀H₄₃FN₄O₁₁
Molecular Weight: 654.68
MDL Number: MFCD01861686
Linear Formula: C₃₀H₄₃FN₄O₁₁
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C1230-1MG	1 mg	$585.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (TLC)
biological source	synthetic (organic)
form	powder
InChI	1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
InChI key	CTXDBLYOEUERAT-VUVYEONESA-N
Quality Level	200
shipped in	dry ice
SMILES string	CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
solubility	DMSO: 20 mM, clear, colorless to light yellow
	methanol: 10 mg/mL
storage temp.	−20°C

Amino Acid Sequence:	Z-Ile-Glu-OMe-Thr-Asp-OMe-FMK
Application:	Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor: • to study the activity of caspase-8 in porcine kidney cells • to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells • to study its effects on retinal ganglion and astroglia in rat eyes
Biochem/physiol Actions:	Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.
Features and Benefits:	This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (TLC)
Storage Temp.	−20°C
UNSPSC	12352209

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