Anti-Calcium Channel (α1 Subunit), Pan antibody produced in rabbit
SIGMA/C1103 - affinity isolated antibody, lyophilized powder
MDL Number: MFCD02095955
Product Type: Chemical
Immunoblotting Anti-Cavpan α1: Cat. No. C1103: Western blot analysis of Rat brain membranes. Lanes 1. Anti-Cavpan α1 antibody, (1:200). 2. Anti-Cavpan α1 antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable using rat heart sections (The epitope can be masked by other subunits in some Ca2+ channels.) |
| western blot: 1:200 using rat brain membranes | |
| UniProt accession no. | P22002  |
| Application: | Anti-Calcium Channel (α1 Subunit), Pan antibody produced in rabbit is suitable for immunohistochemistry (using rat heart sections) and western blotting at a dilution of 1:200 using rat brain membranes. |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunocytochemistry (1 paper) |
| Biochem/physiol Actions: | Calcium channel, voltage-dependent, L type, α1C subunit (Cav1.2) is a protein encoded by the CACNA1C gene in humans and belongs to the family of voltage-gated calcium channels. It serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate different physiological events. CACNA1C is a subunit of L-type voltage-dependent calcium channel. It is mapped to chromosome 12p13.3 and is implicated as a susceptibility gene for schizophrenia. CACNA1C is selectively expressed in human TH2 cells and blockage of Cav1.2 channel activation in TH2 cells may represent new strategies to treat allergic diseases in human subjects. Its increased activity is implicated in the pathogenesis of dementia and Alzheimer′s disease (AD). |
| Biochem/physiol Actions: | The epitope recognized by this antibody is masked by α2 and δ chains; therefore, the antibody binds only after subunit dissociation using Triton X-100 or other detergents. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | synthetic peptide corresponding to amino acids 1506-1524 of the α1S subunit of rat skeletal muscle voltage-gated calcium channel (VGCC, CP15) (Accession P22002) with additional N-terminal cysteine, conjugated to MBS-KLH. |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |