Cromakalim

SIGMA/C1055

Synonym: (±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol

CAS Number: 94470-67-4
Empirical Formula (Hill Notation): C₁₆H₁₈N₂O₃
Molecular Weight: 286.33
MDL Number: MFCD00133201
Linear Formula: C₁₆H₁₈N₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C1055-10MG	10 mg	$234.00 1/EA	Add To Favorites
45-C1055-50MG	50 mg	$1040.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

form	powder
InChI	1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
InChI key	TVZCRIROJQEVOT-CABCVRRESA-N
Quality Level	200
SMILES string	CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N
storage temp.	2-8°C

Application:	Cromakalim has been used: • as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels. • as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens. • as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.
Biochem/physiol Actions:	Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.
Features and Benefits:	This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352200

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