Anti-CRTH2 (GRP44) antibody produced in rabbit
SIGMA/C0867 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Chemoattractant Receptor-homologous Molecule expressed on TH2 Cells; Anti-Putative G-Protein Coupled Receptor 44
MDL Number: MFCD08064414
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~43 kDa by calculation |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| technique(s) | western blot: 1:500-1:1,000 using CRTH2-transfected Jurkat cells |
| Application: | Anti-CRTH2 (GRP44) antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:1,000 using CRTH2- transfected Jurkat cells. |
| Biochem/physiol Actions: | CRTH2 (chemoattractant receptor-homologous molecule), is known as the putative G protein-coupled receptor (GP44), is expressed on T helper 2 (Th2) cells. It is also referred as DP2, DL1R and CD294. It′s a human protein and belongs to G protein-coupled leukocyte chemo attractant receptor family. It is not expressed on human amniocytes or myocytes. On activation of CRTH2, PGD(2) induces human osteoclast apoptosis and the apoptosis intrinsic pathway. CRTH2, CD4 and T cells all together may be involved in the pathogenesis of IgG4-related Lacrimal gland enlargement (LGE) causing Mikulicz′s disease (MD). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | peptide corresponding to the human CRTH2 (GRP44) protein, near the C-terminus (amino acids 329-348). |
| Physical form: | Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |