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Clozapine N-oxide

SIGMA/C0832

Synonym: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide

CAS Number: 34233-69-7
Empirical Formula (Hill Notation): C18H19ClN4O
Molecular Weight: 342.82
MDL Number: MFCD00210190
Linear Formula: C18H19ClN4O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C0832-5MG 5 mg
 $239.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C0832-5MG

 

form solid
InChI 1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key OGUCZBIQSYYWEF-UHFFFAOYSA-N
Quality Level 200 
SMILES string C[N+]1([O-])CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
Application: Clozapine N-oxide has been used:
• for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
• for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
• in behavioral testing in mice and for stimulating (HEK293) cells
Biochem/physiol Actions: 5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.
Biochem/physiol Actions: 5-HT2 serotonin receptor antagonist; major metabolite of clopazine.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.
Packaging: 5 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301 - H336
Precautionary statements P301 + P310 + P330
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 12352119

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