Cyclophosphamide monohydrate

SIGMA/C0768 - bulk package

Synonym: 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; Cytoxan

CAS Number: 6055-19-2
Empirical Formula (Hill Notation): C₇H₁₅Cl₂N₂O₂P · H₂O
Molecular Weight: 279.10
EC Number: 200-015-4
MDL Number: MFCD00149395
Linear Formula: C₇H₁₅Cl₂N₂O₂P · H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C0768-1G	1 g	$75.20 1/EA	Add To Favorites
45-C0768-5G	5 g	$267.00 1/EA	Add To Favorites
45-C0768-10G	10 g	$476.00 1/EA	Add To Favorites
45-C0768-25G	25 g	$1020.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C0768-10G.

Properties
Descriptions
Safety Info.
Basic Data

assay	97.0-103.0% (HPLC)
form	powder
InChI	1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
InChI key	PWOQRKCAHTVFLB-UHFFFAOYSA-N
mp	49-51 °C (lit.)
Quality Level	200
SMILES string	[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1
storage temp.	2-8°C

Application:	Cyclophosphamide monohydrate has been used: • to test its antitumor effect on TC-1 tumor cells • as a component of multidrug solution for isolation of resistant human burkitt lymphoma cell line • in testing antitumor immunity in mouse tumor cell lines
Biochem/physiol Actions:	Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Biochem/physiol Actions:	Cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations.
Features and Benefits:	This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	Cyclophosphamide (CYC) is a cytotoxic alkylating agent. It is activated by the cytochrome P-450 enzyme system in the liver. It has immunomodulatory functionality and inhibits humoral and cellular immunity.Cyclophosphamide exhibits anti-cancer and immunosuppressant activities. In the body, cyclophosphamide is converted by the liver to an active alkylating 4-hydroxycyclophosphamide metabolite, thereby showing its anti-neoplastic effects.
Packaging:	1, 5, 10, 25 g in glass bottle

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 - H340 - H350 - H360FD
Precautionary statements	P202 - P264 - P270 - P280 - P301 + P310 - P405
Hazard Codes	T
Risk Statements	45-25
Safety Statements	53-45
RIDADR	UN 3464 6.1 / PGIII
WGK Germany	WGK 3

Purity	97.0-103.0% (HPLC)
mp	49-51 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	51112507

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