CI−994
SIGMA/C0621 - ≥98% (HPLC), powder
Synonym: 4-Acetylamino-N-(2′-aminophenyl)benzamide; Acetyldinaline; Tacedinaline
CAS Number: 112522-64-2
Empirical Formula (Hill Notation): C15H15N3O2
Molecular Weight: 269.30
MDL Number: MFCD00866266
Linear Formula: C15H15N3O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | off-white |
| form | powder |
| InChI | 1S/C15H15N3O2/c1-10(19)17 |
| InChI key | VAZAPHZUAVEOMC-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC(=O)Nc1ccc(cc1)C(=O)Nc2 |
| solubility | DMSO: >10 mg/mL |
| storage temp. | room temp |
| Application: | CI-994 has been used: • as an histone deacetylase (HDAC) inhibitor to treat SUM229 and DT22 cells to study its effects • as an HDAC inhibitor for screening in SPEL cells • to study its effects on human myeloid and erythroid progenitors |
| Biochem/physiol Actions: | CI-994 is the acetylated derivative form of the original compound Dinaline (PD 104 208). It is an oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells. It is used for combination therapy for selected tumors including non-small cell lung, pancreatic, breast, and colorectal cancers. It acts as a histone deacetylase inhibitor. CI-994 blocks cells in the G1-S phase of the cell cycle. The 16 kDa phosphoprotein is confined to the nuclear compartment. Loss of the 16-kDa nuclear phosphoprotein appears to be a direct effect of CI-994 treatment and that the inhibition of this phosphoprotein may play a critical role in the mechanism of action of CI-994. |
| Biochem/physiol Actions: | Orally available HDAC Inhibitor; CI-994 blocks cells in the G1-S phase of the cell cycle. |
| Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |