CRT0044876
SIGMA/C0496 - ≥98% (HPLC)
Synonym: 7-
CAS Number: 6960-45-8
Empirical Formula (Hill Notation): C9H6N2O4
Molecular Weight: 206.15
EC Number: 230-154-6
MDL Number: MFCD00044720
Linear Formula: C9H6N2O4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| form | powder |
| InChI | 1S/C9H6N2O4/c12-9(13)6-4- |
| InChI key | BIUCOFQROHIAEO-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | OC(=O)c1cc2cccc([N+]([O-] |
| solubility | DMSO: >20 mg/mL |
| storage temp. | room temp |
| Biochem/physiol Actions: | CRT0044876 targets the APE1 active site and inhibits 3′-phosphodiesterase and 3′-phosphatase activities. |
| Biochem/physiol Actions: | CRT0044876 targets the apurinic endonuclease (APE1) active site and inhibits its 3′-phosphodiesterase and 3′-phosphatase activities—essential steps in excision repair—with minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentrations as high as 100 μM. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H319 - H334 |
| Precautionary statements | P261 - P305 + P351 + P338 - P342 + P311 |
| Hazard Codes | Xi |
| Risk Statements | 36-43 |
| Safety Statements | 26-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |