Cambinol
SIGMA/C0494 - ≥97% (HPLC), white, powder
Synonym: 5-
CAS Number: 14513-15-6
Empirical Formula (Hill Notation): C21H16N2O2S
Molecular Weight: 360.43
MDL Number: MFCD09057543
Linear Formula: C21H16N2O2S
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts C0494-25MG
| assay | ≥97% (HPLC) |
| color | white |
| form | powder |
| InChI | 1S/C21H16N2O2S/c24-18-11- |
| InChI key | RVNSQVIUFZVNAU-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Oc1ccc2ccccc2c1CC3=C(NC(= |
| solubility | DMSO: ≥10 mg/mL |
| storage temp. | room temp |
| Application: | Cambinol has been used: • as an inhibitor of sirutins (SIRT1 and 2) in hepatocarcinoma cell lines to test its effect on cellular viability and colony formation • as a SIRT1 and SIRT2 inhibitor to test its effect on frizzled 7 (FZD7) expression in the breast cancer cells MDA-MB-231 and T-47D cells • as a sirutin inhibitor in L929 cells to test its protective effect against tumor necrosis factor (TNF)-induced cell death |
| Biochem/physiol Actions: | Cambinol is a Sirtuin (Human Silent Information Regulator) Type 1/2 Inhibitor. |
| Biochem/physiol Actions: | Cambinol is a Sirtuin (Human Silent Information Regulator) Type 1/2 Inhibitor. Sirtuins are structurally and mechanistically unrelated to HDACs Class 1 & 2 deacetylases but share many protein targets. HDAC is a large complex enzyme family involved in epigenetic-control of gene expression. Sirt2 has an IC50 equal to 59 μM. |
| Biochem/physiol Actions: | Cambinol, a β-naphthol compound, elicits antitumor activity and impairs the mitogen-activated protein kinase (MAPK) signaling. It has ability to inhibit the secretion of inflammatory cytokines including the tumor necrosis factor and interleukins. Cambinol can be a potential therapeutic agent for treating inflammatory diseases. It also aids protection in events of endotoxic and septic shock. |
| Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |