Z-Leu-Leu-Glu-7-amido-4-methylcoumarin

SIGMA/C0483 - ≥95%, solid

Synonym: Cbz-Leu-Leu-Glu-AMC; Z-LLE-AMC

Empirical Formula (Hill Notation): C₃₅H₄₄N₄O₉
Molecular Weight: 664.75
MDL Number: MFCD01074989
Linear Formula: C₃₅H₄₄N₄O₉
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C0483-5MG	5 mg	$457.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
form	solid
InChI	1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1
InChI key	FOYHOBVZPWIGJM-KCHLEUMXSA-N
Quality Level	200
SMILES string	CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
solubility	DMSO: soluble
storage temp.	−20°C

Amino Acid Sequence:	Z-Leu-Leu-Glu-AMC
Application:	Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.
Biochem/physiol Actions:	Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.
Biochem/physiol Actions:	Fluorogenic substrate to measure peptidylglutamyl-peptide hydrolyzing activity of 20S proteasome.
General description:	Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	−20°C
UNSPSC	12352209

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