Calcitonin Gene Related Peptide rat
SIGMA/C0292 - ≥95% (HPLC), powder
Synonym: α-CGRP; CGRP-I
CAS Number: 96827-03-1
Empirical Formula (Hill Notation): C162H262N50O52S2
Molecular Weight: 3806.25
MDL Number: MFCD00081460
Linear Formula: C162H262N50O52S2
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| biological source | rat |
| form | powder |
| mol wt | 3803.25-3809.25 Da |
| Quality Level | 200  |
| sequence note | Ser-Cys-Asn-Thr-Ala-Thr-C |
| storage temp. | −20°C |
| technique(s) | cell based assay: suitable |
| UniProt accession no. | P01257  |
| P01256 |
| Amino Acid Sequence: | Ser-Cys-Asn-Thr-Ala-Thr-C |
| Application: | Calcitonin Gene Related Peptide rat has been used:• To study its protective role in lipopolysaccharide (LPS)-induced acute lung injury (ALI). • To examine the effects of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric lesions and mucosal barrier in stress induced rats. • To mediate the complement component 5a (C5a) induced mechanical hypersensitivity by activating nerve fibers and influencing non-neuronal cell movement through its receptor. |
| Biochem/physiol Actions: | Calcitonin gene related peptide (CGRP) is a potent vasodilator produced from sensory fibers, acting as transmitters in the peripheral and central nervous system, thereby exerting its role in regulating pain and cardiovascular activity. CGRPs play an important role in regulating systemic blood pressure, and microvascular dilatation and are associated with hyperemia. It stimulates edema in orofacial tissue and its activation in pancreatic β-cells increases plasma levels of pancreatic enzymes. In addition, CGRP also induces DNA synthesis and cell proliferation in endothelial cells. |
| Biochem/physiol Actions: | Potent, long-lasting vasodilator. |
| Biochem/physiol Actions: | Potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes. |
| General description: | Research area: Neuroscience Calcitonin gene related peptide (CGRP) is a 37 amino acid neuropeptide. It exists in two isoforms α-CGRP and β-CGRP. CGRP is produced by the alternative splicing of the calcitonin gene (CALCA). They are primarily localized in the C and Aδ sensory fibers, but are also present in non-neuronal tissues, like the cardiovascular system. |
| Other Notes: | Lyophilized from 0.1% TFA in H2O |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |