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BAY 61-3606 hydrochloride hydrate

SIGMA/B9685 - ≥98% (HPLC), powder

Synonym: 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide hydrochloride

Empirical Formula (Hill Notation): C20H18N6O3 · xHCl · yH2O
Molecular Weight: 390.40 (anhydrous free base basis)
MDL Number: MFCD29073361
Linear Formula: C20H18N6O3 · xHCl · yH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B9685-5MG 5 mg
 $442.00
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assay ≥98% (HPLC)
color yellow
form powder
InChI 1S/C20H18N6O3.ClH.H2O/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H;1H2
InChI key WYXPKEXHEJAVSI-UHFFFAOYSA-N
originator Bayer
potency 7.5 nM Ki
Quality Level 100 
SMILES string O.Cl.COc1ccc(cc1OC)-c2cc3nccn3c(Nc4ncccc4C(N)=O)n2
solubility H2O: soluble
storage condition desiccated
storage temp. 2-8°C
Application: BAY 61-3606 hydrochloride hydrate has been used in focal cerebral ischemia model. It has also been used to assess the effect of Syk in stroke-induced injury.
Biochem/physiol Actions: BAY 61-3606 helps to prevent the degranulation of freshly isolated basophils. It also prevents B cell receptor (BCR)-mediated signaling.
Biochem/physiol Actions: Spleen tyrosine kinase (Syk) inhibitor; anti-inflammatory. Syk plays a major role in inflammation pathways via receptors for the Fc portion of immunoglobulins, as well as B cell signaling. It is orally active, potent (Ki 7.5 nM), and highly selective for Syk vs other kinases (Lyn, Fyn, Src, Itk, Btk; Ki′s).
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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