Synonym: 7(E)-Benzylidenenaltrexone maleate salt hydrate; BNTX-7 maleate salt hydrate; Morphinan-6-one,17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-7-(phenylmethylene)-,(5a,7E)- maleate salt hydrate
Empirical Formula (Hill Notation): C31H31NO8 · xH2O
Molecular Weight: 545.58 (anhydrous basis)
MDL Number: MFCD12912399
Linear Formula: C31H31NO8 · xH2O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
yellow |
| form |
powder |
| InChI |
1S/C27H27NO4.C4H4O4.H2O/c29-20-9-8-18-13-21-27(31)14-19(12-16-4-2-1-3-5-16)23(30)25-26(27,22(18)24(20)32-25)10-11-28(21)15-17-6-7-17;5-3(6)1-2-4(7)8;/h1-5,8-9,12,17,21,25,29,31H,6-7,10-11,13-15H2;1-2H,(H,5,6)(H,7,8);1H2/b19-12+;2-1-;/t21-,25+,26+,27-;;/m1../s1 |
| InChI key |
AGUNLJBLOJAUKM-ZKJXOIBSSA-N |
| Quality Level |
100  |
| SMILES string |
O.OC(=O)C=C/C(O)=O.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)C(C[C@@]35O)=Cc6ccccc6)CC7CC7 |
| solubility |
DMSO: >20 mg/mL |
| storage condition |
desiccated |
| storage temp. |
−20°C |
| Application: |
BNTX, a selective nonpeptide σ1 opioid receptor (DOR1) antagonist, is used in σ opioid receptor research to help differentiate and characterized the function and role of the σ1 opioid receptor versus other σ opioid receptor subtypes. BNTX was used to help define the role of σ1 opioid receptors in neurological processes such as anxiety. It was used to help define the role of σ opioid receptors in myocardial infarct development and size. |
| Biochem/physiol Actions: |
BNTX is a selective d1 non peptide opioid receptor antagonist. |
| Biochem/physiol Actions: |
BNTX is a selective nonpeptide δ1 opioid receptor antagonist. It antagonizes the effect of D-Pen2,5-enkephalin (a δ1 agonist 4-6 fold, but did not affect the activity of δ2 or μ agonists.<<<107>>> BNTX is used to discriminate among opioid receptor subtypes in effects such as alcohol and drug dependence. It binds 100× more tightly to δ1 than to δ2 receptors. In the tail-flick assay, antinocieceptive ED50 = 646.4 pmol/mouse. |
| Features and Benefits: |
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
5, 25 mg in glass bottle |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
GHS07,GHS09