8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt

SIGMA/B7880 - ≥97% (HPLC), powder

Synonym: 8-Br-cAMP

CAS Number: 76939-46-3
Empirical Formula (Hill Notation): C₁₀H₁₀BrN₅NaO₆P
Molecular Weight: 430.08
MDL Number: MFCD00005844
Linear Formula: C₁₀H₁₀BrN₅NaO₆P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-B7880-5MG	5 mg	$46.80 1/EA	Add To Favorites
45-B7880-25MG	25 mg	$152.00 1/EA	Add To Favorites
45-B7880-100MG	100 mg	$445.00 1/EA	Add To Favorites
45-B7880-250MG	250 mg	$894.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B7880-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	off-white
form	powder
InChI	1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
InChI key	DMRMZQATXPQOTP-GWTDSMLYSA-M
Quality Level	200
SMILES string	[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc12
solubility	H₂O: 100 mg/mL
storage temp.	−20°C

Application:	8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used: • to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture • used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei • in superfusion medium for head kidneys stimulation
Biochem/physiol Actions:	Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.
Biochem/physiol Actions:	Cell-permeable cAMP analog with greater resistance to hydrolysis by phosphodiesterases than cAMP.
Disclaimer:	Sensitive to light and moisture.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.
Other Notes:	Membrane-permeable cAMP analog.
Packaging:	100, 250 mg in poly bottle
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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