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1(S),9(R)-(−)-Bicuculline methbromide

SIGMA/B7561 - ≥98% (HPLC), solid

Synonym: (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1)

CAS Number: 66016-70-4
Empirical Formula (Hill Notation): C21H20BrNO6
Molecular Weight: 462.29
MDL Number: MFCD00055149
Linear Formula: C21H20BrNO6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B7561-25MG 25 mg
 $200.00
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45-B7561-125MG 125 mg
 $798.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts B7561-25MG

 

assay ≥98% (HPLC)
color white to off-white
form solid
InChI 1S/C21H20NO6.BrH/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18-,19+;/m0./s1
InChI key BWXCECYGGMGBHD-GRTNUQQKSA-M
Quality Level 100 
SMILES string [Br-].C[N+]1(C)CCc2cc3OCOc3cc2[C@H]1[C@@H]4OC(=O)c5c6OCOc6ccc45
solubility H2O: >10 mg/mL
storage temp. 2-8°C
Application: 1(S),9(R)-(-)-Bicuculline methbromide has been used:
• as a γ-aminobutyric acid (GABAA) receptor A antagonist: in cortical neuron culture
• in artificial cerebrospinal fluid (ACSF) formature dentate granule neurons
• in hypothalamic explant cultures
Biochem/physiol Actions: 1(S),9(R)-(−)-Bicuculline methbromide is a GABAA receptor antagonist, which blocks Ca2+-activated potassium (SK) channels. It is the water-soluble derivative of (+)-bicuculline.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 25, 125 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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