Bryostatin 1

SIGMA/B7431 - ≥99%, solid

Synonym: NSC 339555

CAS Number: 83314-01-6
Empirical Formula (Hill Notation): C₄₇H₆₈O₁₇
Molecular Weight: 905.03
MDL Number: MFCD00893832
Linear Formula: C₄₇H₆₈O₁₇
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-B7431-10UG	10 µg	$252.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99%
color	white
form	solid
InChI	1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1
InChI key	MJQUEDHRCUIRLF-TVIXENOKSA-N
Quality Level	100
SMILES string	[H]C(C(=O)OC)=C1/C[C@@]2([H])C[C@]3(O)O[C@]([H])(C[C@@H](O)CC(=O)O[C@H](C[C@]4([H])CC(=C([H])C(=O)OC)[C@H](OC(=O)C=CC=CCCC)[C@@](O)(O4)C(C)(C)C=C[C@@]([H])(C1)O2)[C@@H](C)O)C[C@H](OC(C)=O)C3(C)C
solubility	DMSO: soluble
	ethanol: soluble
storage temp.	−20°C

Application:	Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis in mice. It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.
Biochem/physiol Actions:	Bryostatin 1 (Bry1) is a macrocyclic lactone. This synaptogenic compound is obtained from the marine bryozoan Bugula neritina. Bry1 is capable of reversing synaptic loss. It can enable synaptic maturation in animal models with several neurological disorders. It possesses antidepressant activity, when administered intracebroventricularly. Bry1 is known to participate in protecting cell tight junctions (TJs), anti-inflammatory functions and immune regulation.
Biochem/physiol Actions:	Macrolactone isolated from the marine bryozoan Bugula neritina that initially activates and subsequently down-regulates protein kinase C (PKC). More potent than phorbol myristate acetate for translocating PKCδ and ε.
Other Notes:	Binds to glass and plastic in aqueous solutions
Packaging:	10 μg in ampule

Hazard Codes	Xn
Risk Statements	68
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99%
Storage Temp.	−20°C
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.