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Brefeldin A

SIGMA/B6542 - BioXtra, ≥99% (HPLC and TLC), Molecular Biology

Synonym: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone; Ascotoxin; BFA; Cyanein; Decumbin

CAS Number: 20350-15-6
Empirical Formula (Hill Notation): C16H24O4
Molecular Weight: 280.36
MDL Number: MFCD12913297
Linear Formula: C16H24O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B6542-5MG 5 mg
 $216.00
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45-B6542-25MG 25 mg
 $701.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B6542-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B6542-5MG

 

antibiotic activity spectrum neoplastics
assay ≥99% (HPLC and TLC)
biological source Penicillium brefeldianum
form powder
grade Molecular Biology
InChI 1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
InChI key KQNZDYYTLMIZCT-KQPMLPITSA-N
mode of action protein synthesis | interferes
mol wt 280.36
product line BioXtra
Quality Level 300 
SMILES string C[C@H]1CCCC=C[C@@H]2C[C@H](O)C[C@H]2[C@H](O)C=CC(=O)O1
solubility DMSO: 10 mg/mL (Store stock solutions at -20 °C)
storage temp. 2-8°C
Application: Suitable for molecular biology studies of secretory proteins and mechanisms of intracellular transport
Biochem/physiol Actions: Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Biochem/physiol Actions: Brefeldin is a fungal metabolite that disrupts protein secretion in eukaryotic cells by disrupting the Golgi apparatus. It does not affect the process of protein synthesis.
Biochem/physiol Actions: Disrupts the structure and function of the Golgi apparatus; activator of the sphingomyelin cycle.
General description: Brefeldin induces ADP-ribosylation of CtBP1/BARS protein that regulates the intracellular trafficking and movement of secretory proteins from endoplasmic reticulum to Golgi apparatus.
General description: Chemical structure: macrolide
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes Xn
Risk Statements 22
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥99% (HPLC and TLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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