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Bisantrene dihydrochloride

SIGMA/B4563 - ≥98% (HPLC)

Synonym: Bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone)-9,10-anthracenedicarboxaldehyde dihydrochloride; NSC 337766

CAS Number: 78186-34-2
Empirical Formula (Hill Notation): C22H22N8 ·2HCl
Molecular Weight: 471.39
MDL Number: MFCD01743164
Linear Formula: C22H22N8 ·2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B4563-10MG 10 mg
 $95.70
1/EA		 Add To Favorites
45-B4563-50MG 50 mg
 $381.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form solid
InChI 1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+;;
InChI key KINULKKPVJYRON-PVNXHVEDSA-N
Quality Level 100 
SMILES string Cl.Cl.C1CN=C(N1)NN=Cc2c3ccccc3c(C=NNC4=NCCN4)c5ccccc25
solubility deionized water: 8 mg/mL
storage condition desiccated
storage temp. room temp
Application: Bisantrene (NSC 337766), and its derivatives are topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor.
Biochem/physiol Actions: Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator and topoisomerase II poison
Biochem/physiol Actions: Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein.
Biochem/physiol Actions: Bisantrene is an anthracene bishydrazone derivative, which has antitumor activity.
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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