Bisindolylmaleimide X hydrochloride
SIGMA/B3931 - ≥90%, solid
Synonym: Ro 31-8425
CAS Number: 145317-11-9
Empirical Formula (Hill Notation): C26H24N4O2 · HCl
Molecular Weight: 460.96
MDL Number: MFCD04972010
Linear Formula: C26H24N4O2 · HCl
Product Type: Chemical
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| assay | ≥90% |
| biological source | synthetic (organic) |
| form | solid |
| InChI | 1S/C26H24N4O2.ClH/c1-29-1 |
| InChI key | IMBOYWXMTUUYGZ-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | Cl.Cn1cc(C2=C(C(=O)NC2=O) |
| solubility | DMSO: soluble |
| storage temp. | −20°C |
| Application: | Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor: • in chemotaxis assays • to inhibit protein kinase C and to study its effects on the expression of EGR1, NAB2, ZEBRA, and Rta • in the culture to study its effects on the expression of the kinase-insert domain-containing receptor (KDR)-B1, protein kinase Cθ (PKCθ)-M1a or Abl-HTa and on cell yield in baculovirus (BV)-infected insect cells |
| Biochem/physiol Actions: | Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKC in vitro with an IC50 of 5nM. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% |
| Storage Temp. | −20°C |
| UNSPSC | 12352111 |