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BAY U6751 hydrate

SIGMA/B3686 - solid, ≥98% (HPLC)

Synonym: 4-(2-Chlorophenyl)-1-ethyl-1,4-dihydro-6-methyl-2,3,5-pyridinetricarboxylic acid 5-isopropyl ester disodium salt hydrate

CAS Number: 114290-51-6 (anhydrous)
Empirical Formula (Hill Notation): C20H20ClNNa2O6 · xH2O
Molecular Weight: 451.81 (anhydrous basis)
MDL Number: MFCD08705410
Linear Formula: C20H20ClNNa2O6 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B3686-5MG 5 mg
 $272.00
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45-B3686-25MG 25 mg
 $866.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts B3686-5MG

 

assay ≥98% (HPLC)
color white
form solid
InChI 1S/C20H22ClNO6.2Na.H2O/c1-5-22-11(4)14(20(27)28-10(2)3)15(12-8-6-7-9-13(12)21)16(18(23)24)17(22)19(25)26;;;/h6-10,15H,5H2,1-4H3,(H,23,24)(H,25,26);;;1H2/q;2*+1;/p-2
InChI key QECLOEJXLYHXNF-UHFFFAOYSA-L
originator Bayer
Quality Level 100 
SMILES string [Na+].[Na+].[H]O[H].CCN1C(C)=C(C(c2ccccc2Cl)C(C([O-])=O)=C1C([O-])=O)C(=O)OC(C)C
solubility H2O: >8 mg/mL
storage condition protect from light
storage temp. 2-8°C
Biochem/physiol Actions: BAY U6751 is a glycogen phosphorylase inhibitor. Formed from the prodrug, BAYR3401. BAY U6751 exists as the enantiomeric mixture. BAY W1807 is the active metabolite.
Biochem/physiol Actions: BAY W1807, the active metabolite of BAY R3401, inhibits muscle glycogen phosphorylase a and b. In gel-filtered liver extracts, racemic BAY U6751 (containing active BAY W1807) was tested for inhibition of phosphorylase in the glycogenolytic (in which only phosphorylase a is active). In liver extracts, BAY U6751 (0.9-36 μmol/L) inhibited glycogen synthesis by phosphorylase b (notwithstanding the inclusion of AMP), but not by phosphorylase a. Inhibition of phosphorylase-a-catalyzed glycogenolysis was partially relieved by AMP (500 μmol/L). BAY U6751 facilitated phosphorylase-a dephosphorylation. Isolated hepatocytes and perfused livers were tested for BAY R3401-induced changes in phosphorylase-a:b ratios and glycogenolytic output.
Disclaimer: Light sensitive. Store in amber vials.
Features and Benefits: This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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