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Pentagastrin

SIGMA/B1636 - ≥95% (HPLC), powder

Synonym: Peptavlon; Petogasrin; N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide

CAS Number: 5534-95-2
Empirical Formula (Hill Notation): C37H49N7O9S
Molecular Weight: 767.89
EC Number: 226-889-7
MDL Number: MFCD00076515
Linear Formula: C37H49N7O9S
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-B1636-25MG 25 mg
$293.00
1/EA
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45-B1636-100MG 100 mg
$999.00
1/EA
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assay ≥95% (HPLC)
color white to off-white
form powder
InChI 1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)
InChI key NEYNJQRKHLUJRU-UHFFFAOYSA-N
Quality Level 200 
SMILES string CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O
solubility DMF: 20 mg/mL, clear, colorless to faint yellow or tan
storage condition (Keep container tightly closed in a dry and well-ventilated place.)
storage temp. −20°C
Amino Acid Sequence: Boc-Bal-Trp-Met-Asp-Phe-NH2
Application: Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity. It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.
Biochem/physiol Actions: Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin. It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist. Pentagastrin stimulates the secretion of pepsin and gastric acid. It also aids in the evaluation of gastric acid secretory function. Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.
General description: Research area: Immunology & cytokines
Packaging: 25, 100 mg in serum bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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