Anti-PCDH15 antibody produced in rabbit
SIGMA/AV50153 - affinity isolated antibody
Synonym: Anti-DFNB23; Anti-DKFZp667A1711; Anti-Protocadherin 15; Anti-RP11-449J3.2; Anti-USH1F
Product Type: Chemical
Western Blotting JOURNAL CITATION: Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells. By: Monticone, M., Daga, A., et al. in BMC Cancer, 2012. PubMed ID: 22901239 Image collected and cropped by CiteAb from the following publication, (http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-358), provided under a CC-BY license. Image might reflect a new usage that is not reflected in claims on product description or independently verified by Merck KGaA, Darmstadt, Germany. For Research Use Only. Not for use in diagnostic procedures.
Immunoblotting Cell Type: HepG2 (Cat. No. AV50153). Lanes 1. Antibody dilution (concentration) 1 μg/mL in cell type HepG2
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 80 kDa |
| NCBI accession no. | NP_149045   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, guinea pig, rat, rabbit, mouse, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | A2A3E5 |
| Application: | Anti-PCDH15 antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml. |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Western Blotting (1 paper) |
| Biochem/physiol Actions: | The expression of Protocadherin-related 15 (PCDH15) is essential for normal function of cochlea and retina. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). PCDH15 is expressed in nasal NK/T-cell lymphomas. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The gene Protocadherin-related 15 (PCDH15) is mapped to human chromosme 10q21.1. It is an integral membrane protein and one of the members of the cadherin superfamily that mediate calcium-dependent cell-cell adhesion.. PCDH15 transcripts can be detected in adult brain, lung, kidney, fetal retina and fetal cochlea. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human PCDH15 |
| Other Notes: | Synthetic peptide located within the following region: HSIVVQVQCINKKVGTIIYHEVRIV |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |