Anti-MTF1 antibody produced in rabbit
SIGMA/AV32027 - IgG fraction of antiserum
Synonym: Anti-
Product Type: Chemical
Immunoblotting Cell Type: HepG2 (Cat. No. AV32027). Lanes 1. Antibody dilution (concentration) 5.0 μg/mL in cell type HepG2
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 81 kDa |
| NCBI accession no. | NP_005946   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, dog, mouse, bovine, horse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q14872 |
| Application: | Rabbit Anti-MTF1 antibody can be used for western blot applications at a concentration of 5.0μg/ml. |
| Biochem/physiol Actions: | The zinc finger transcription factor MTF-1 (metal-responsive transcription factor-1) is conserved from insects to vertebrates. The major role of MTF-1 in both organisms is to control the transcription of genes involved in the homeostasis and detoxification of heavy metal ions such as Cu2+, Zn2+ and Cd2+. In mammals, MTF-1 serves at least two additional roles. First, targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration, revealing a stage-specific developmental role. Second, under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene placental growth factor (PIGF), an angiogenic protein. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Metal-response element-binding transcription factor 1 (MTF1) is a cellular zinc sensor that is involved in zinc homeostasis. MTF1 is also known to protect against oxidative stress and metal toxicity. Furthermore, MTF1 can modulate metallothionein gene expression. Rabbit Anti-MTF1 antibody recognizes human, mouse, rat, bovine, and canine MTF1. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human MTF1 |
| Other Notes: | Synthetic peptide located within the following region: QSSLVMGEQNLQWILNGATSSPQNQ |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |