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3-Acetyl-11-keto-β-boswellic acid

SIGMA/A9855 - from Boswellia serrata

Synonym: AKBA

CAS Number: 67416-61-9
Empirical Formula (Hill Notation): C32H48O5
Molecular Weight: 512.72
MDL Number: MFCD03788777
Linear Formula: C32H48O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A9855-5MG 5 mg
 $429.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A9855-5MG

 

application(s) metabolomics
vitamins, nutraceuticals, and natural products
biological source Boswellia serrata
form powder
InChI 1S/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32-/m1/s1
InChI key HMMGKOVEOFBCAU-BCDBGHSCSA-N
Quality Level 200 
SMILES string O([C@H]1[C@]([C@H]2[C@@]([C@@H]3[C@]([C@@]4(CC[C@@]5([C@@H]([C@H]([C@@H](CC5)C)C)C4=CC3=O)C)C)(CC2)C)(CC1)C)(C)C(=O)O)C(=O)C
storage temp. −20°C
Application: 3-Acetyl-11-keto-β-boswellic acid (AKBA) has been used:
• to test its effects as an anti-proliferating agent on hepatic stellate cells (HSCs) proliferation and synergism in combination with imatinib in in vitro models
• to study its anti-osteoporotic activity on ovariectomy-induced osteoporosis in female Sprague Dawley rats
• in a comparative study with aspirin to test its effects as an anti-inflammatory drug to prevent intestinal adenomatous polyposis in APCMin/+ mice
Biochem/physiol Actions: Acetyl-11-keto-beta-boswellic acid is a pentacyclic triterpene that inhibits 5-lipoxygenase in a selective, enzyme-directed, nonredox, and noncompetitive manner. It has also been shown to inhibit topoisomerase I and NF-κB signaling.
Biochem/physiol Actions: Acetyl-11-keto-β-boswellic acid (AKBA) displays antibacterial and anti-biofilm activities against Staphylococcus epidermidis and S. aureus, respectively. It is an activator of nuclear factor erythroid-2-related factor 2 (Nrf2) and exerts neuroprotective properties against ischemic injury in both in vitro and in vivo studies.
General description: Acetyl-11-keto-β-boswellic acid (AKBA) is extracted from the resin of Boswellia serrata.
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352106

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