Amyloid β Protein Fragment 1-42
SIGMA/A9810
CAS Number: 107761-42-2
Empirical Formula (Hill Notation): C203H311N55O60S
Molecular Weight: 4514.04
MDL Number: MFCD00163049
Linear Formula: C203H311N55O60S
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| form | powder |
| InChI | 1S/C203H311N55O60S/c1-28- |
| InChI key | DZHSAHHDTRWUTF-SIQRNXPUSA |
| Quality Level | 200  |
| SMILES string | S(CC[C@H](NC(=O)[C@@H](NC |
| storage temp. | −20°C |
| UniProt accession no. | P05067  |
| Amino Acid Sequence: | Asp-Ala-Glu-Phe-Arg-His-A |
| Application: | Amyloid β Protein Fragment 1-42 has been used: • for the preparation of Aβ 1-42 oligomer • for western blot analysis • for the interference test of immunomagnetic reduction (IMR) plasma Aβ42 assay • to study the effects of resveratrol on Aβ 1-42-induced impairment of spatial learning, memory and synaptic plasticity • to investigate the effect of Aβ in epithelial cell culture |
| Biochem/physiol Actions: | Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties. |
| Biochem/physiol Actions: | The predominant fragment of amyloid β-protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome. |
| General description: | Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |