Anisomycin from Streptomyces griseolus

SIGMA/A9789 - ≥98% (HPLC), solid

Synonym: (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate; 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate; Flagecidin

CAS Number: 22862-76-6
Empirical Formula (Hill Notation): C₁₄H₁₉NO₄
Molecular Weight: 265.30
EC Number: 245-269-7
MDL Number: MFCD00077650
Linear Formula: C₁₄H₁₉NO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A9789-5MG	5 mg	$57.90 1/EA	Add To Favorites
45-A9789-25MG	25 mg	$196.00 1/EA	Add To Favorites
45-A9789-100MG	100 mg	$586.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A9789-100MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
assay	≥98% (HPLC)
color	white to faint yellow
form	solid
InChI	1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
InChI key	YKJYKKNCCRKFSL-RDBSUJKOSA-N
mode of action	protein synthesis \| interferes
Quality Level	300
SMILES string	COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1
solubility	DMSO: 20 mg/mL
	H₂O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.)
	methanol: 20 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
Biochem/physiol Actions:	Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH₂ terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.
Disclaimer:	Hygroscopic
Packaging:	5, 25, 100 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P264 - P270 - P301 + P310 - P405 - P501
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 3462 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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