Adefovir dipivoxil
SIGMA/A9730
Synonym: 9-
CAS Number: 142340-99-6
Empirical Formula (Hill Notation): C20H32N5O8P
Molecular Weight: 501.47
MDL Number: MFCD00869897
Linear Formula: C20H32N5O8P
Product Type: Chemical
| antibiotic activity spectrum | viruses |
| assay | ≥98% (HPLC) |
| biological source | synthetic |
| form | powder |
| InChI | 1S/C20H32N5O8P/c1-19(2,3) |
| InChI key | WOZSCQDILHKSGG-UHFFFAOYSA |
| mode of action | enzyme | inhibits |
| Quality Level | 100 ![]() |
| SMILES string | CC(C)(C)C(=O)OCOP(=O)(COC |
| solubility | ethanol: 50 mg/mL |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog that works by blocking reverse transcriptase. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1). Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages . |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. |
| Symbol | GHS07 |
| Signal word | Warning |
| Hazard statements | H302 + H312 + H332 |
| Precautionary statements | P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51102829 |


