Alexidine dihydrochloride
SIGMA/A8986 - ≥95% (HPLC)
Synonym: 1,1′-Hexamethylene-bis(5-[2-ethylhexyl]biguanide)
CAS Number: 1715-30-6
Empirical Formula (Hill Notation): C26H56N10 · 2HCl
Molecular Weight: 581.71
EC Number: 216-994-6
MDL Number: MFCD00082369
Linear Formula: C26H56N10 · 2HCl
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C26H56N10.2ClH/c1-5-9- |
| InChI key | BRJJFBHTDVWTCJ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl.Cl.CCCCC(CC)CNC(=N)NC( |
| solubility | DMSO: ≥10 mg/mL |
| storage condition | desiccated |
| storage temp. | −20°C |
| Application: | Alexidine dihydrochloride has been used: • as an antiseptic to study its antimicrobial activity in saliva-derived microcosm biofilms • as a protein tyrosine phosphatase localized to the mitochondrion 1 (PTPMT1)-specific inhibitor to study its effects on spare respiratory capacity and viability of CD8+ T cells • as a PTPMT1 inhibitor to study its antiviral effect on human cytomegalovirus (HCMV) replication in HCMV-infected human foreskin fibroblast (HFF) cells |
| Biochem/physiol Actions: | Alexidine dihydrochloride is a bisbiguanide compound. It has been studied in the treatment of head and neck cancer. Alexidine dihydrochloride also exhibits antibiofilm and antifungal activity against several fungal species. It causes mitochondrial apoptosis in mammalian cells due to its anti-cancer activity. Alexidine dihydrochloride is a component of oral disinfectant and contact lens solution. |
| Biochem/physiol Actions: | Alexidine dihydrochloride is a potent and selective PTPMT1 (Protein Tyrosine Phosphatase Localized to the Mitochondrion 1) inhibitor. Alexidine increases insulin secretion by isolated rat pancreatic islets. |
| Features and Benefits: | This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |