Arg-Gly-Asp
SIGMA/A8052 - ≥97% (TLC)
Synonym: L-
CAS Number: 99896-85-2
Empirical Formula (Hill Notation): C12H22N6O6
Molecular Weight: 346.34
MDL Number: MFCD00057952
Linear Formula: C12H22N6O6
Product Type: Chemical
| assay | ≥97% (TLC) |
| biological source | synthetic |
| form | powder |
| InChI | 1S/C12H22N6O6/c13-6(2-1-3 |
| InChI key | IYMAXBFPHPZYIK-BQBZGAKWSA |
| Quality Level | 200  |
| SMILES string | N[C@@H](CCCNC(N)=N)C(=O)N |
| storage temp. | −20°C |
| technique(s) | cell culture | stem cell: suitable |
| UniProt accession no. | P02751  |
| Amino Acid Sequence: | Arg-Gly-Asp |
| Application: | Arg-Gly-Asp has been used: • to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel • in adhesion assay • in inhibition assay to confirm the β1-integrin-dependency of cell adhesion • in textile fabrication and RGD textile functionalization • to engineer a population of human dermal fibroblasts with impaired migration • to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs) • in the cell culture of human mammary epithelial cells |
| Biochem/physiol Actions: | Primary sequence involved with the binding of proteins to cell surfaces |
| General description: | Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand. |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Preparation Note: | Tripeptide from the cell-attachment domain of fibronectin |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (TLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352209 |