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Amiloride hydrochloride hydrate

SIGMA/A7410 - ≥98% (HPLC), powder

Synonym: N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate

CAS Number: 2016-88-8 (anhydrous)
Empirical Formula (Hill Notation): C6H8ClN7O · HCl · xH2O
Molecular Weight: 266.09 (anhydrous basis)
MDL Number: MFCD03703482
Linear Formula: C6H8ClN7O · HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A7410-1G 1 g
 $78.30
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45-A7410-5G 5 g
 $328.00
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45-A7410-10G 10 g
 $466.00
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assay ≥98% (HPLC)
color , White to Yellow and Faint Green to Green and Yellow-Green
form powder
InChI 1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2
InChI key WDZJJRLYFQNCQL-UHFFFAOYSA-N
mp 285-288 °C (dec.)
originator Perrigo
Quality Level 200 
SMILES string O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
solubility H2O: 50 mg/mL, hazy (Very Faint Yellow to Dark Yellow and Very Faint Green-Yellow to Dark Green-Yellow and Very Faint Brown-Yellow to Dark Brown-Yellow)
storage temp. room temp
Application: Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.
Biochem/physiol Actions: Selective T-type Ca2+ and epithelial sodium channel blocker
Biochem/physiol Actions: Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).
Disclaimer: Protect from light.
Features and Benefits: This compound is a featured product for ADME Tox research. Click here  to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs)  and Imidazoline Binding Sites  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Perrigo . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P330 + P331 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
mp 285-288 °C (dec.)
Storage Temp. room temp
UNSPSC 12352200

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