Amiloride hydrochloride hydrate
SIGMA/A7410 - ≥98% (HPLC), powder
Synonym: N-
CAS Number: 2016-88-8 (anhydrous)
Empirical Formula (Hill Notation): C6H8ClN7O · HCl · xH2O
Molecular Weight: 266.09 (anhydrous basis)
MDL Number: MFCD03703482
Linear Formula: C6H8ClN7O · HCl · xH2O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | , White to Yellow and Faint Green to Green and Yellow-Green |
| form | powder |
| InChI | 1S/C6H8ClN7O.ClH.H2O/c7-2 |
| InChI key | WDZJJRLYFQNCQL-UHFFFAOYSA |
| mp | 285-288 °C (dec.) |
| originator | Perrigo |
| Quality Level | 200  |
| SMILES string | O.Cl.NC(=N)NC(=O)c1nc(Cl) |
| solubility | H2O: 50 mg/mL, hazy (Very Faint Yellow to Dark Yellow and Very Faint Green-Yellow to Dark Green-Yellow and Very Faint Brown-Yellow to Dark Brown-Yellow) |
| storage temp. | room temp |
| Application: | Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation. |
| Biochem/physiol Actions: | Selective T-type Ca2+ and epithelial sodium channel blocker |
| Biochem/physiol Actions: | Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA). |
| Disclaimer: | Protect from light. |
| Features and Benefits: | This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Perrigo . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P330 + P331 + P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| mp | 285-288 °C (dec.) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |