Advanced Search



Angiotensin Converting Enzyme from rabbit lung

SIGMA/A6778 - ≥2.0 units/mg protein (modified Warburg-Christian)

Synonym: ACE; Peptidyl-dipeptidase A; Peptidyldipeptide Hydrolase

CAS Number: 9015-82-1
MDL Number: MFCD00130325
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A6778-.1UN 0.1 unit
 $101.00
1/EA		 Add To Favorites
45-A6778-.25UN 0.25 unit
 $187.00
1/EA		 Add To Favorites
45-A6778-1UN 1 unit
 $522.00
1/EA		 Add To Favorites
45-A6778-2UN 2 units
 $985.00
1/EA		 Add To Favorites
45-A6778-5UN 5 units
 $2100.00
1/EA		 Add To Favorites
Angiotensin II is a systemic vasoconstrictor that causes an increase in blood pressure. Renin, a protease secreted from the kidney, produces angiotensin I by cleaving several amino acids from angiotensinogen. In the next step, angiotensin I is hydrolyzed by ACE (Angiotensin-Converting Enzyme) originating in the lungs, to yield active angiotensin II. Angiotensin II also stimulates the adrenal cortex to secret aldosterione which also causes an increase blood pressure by stimulating sodium reabsorption by the kidney.

 

form lyophilized powder
Quality Level 200 
shipped in dry ice
specific activity ≥2.0 units/mg protein (modified Warburg-Christian)
storage temp. −20°C
Analysis Note: May contain traces of sodium chloride.
Application: Angiotensin converting enzyme from rabbit lung has been used:
• for measuring inhibitory effect of egg white protein hydrolysates on ACE activity by high performance liquid chromatography (HPLC)
• to measure the ACE inhibition by litchi pericarp and cooked chicken breast using hippuryl-L-histidyl-L-leucine (HHL) as substrate by reverse phase-HPLC (RP-HPLC)3 and HPLC respectively
• in releasing GPI anchored protein in vitro in few cell lines like HeLa, HEK293 and in vivo in mice sperm.
Biochem/physiol Actions: Removes C-terminal dipeptides from susceptible substrates, e.g., angiotensin I and bradykinin.
General description: The angiotensin-converting enzyme (ACE) is a dipeptidyl-carboxypeptidase which exists in somatic and testicular isoforms with zinc binding motif HEXXH in their active site. ACE regulates blood pressure through renin-angiotensin system. ACE elevates blood pressure by converting angiotensin I to a key vasoconstrictor angiotensin II and inhibiting a potent vasodilator bradykinin. Inhibition of ACE is a targeted therapeutic strategy for high blood pressure. Several ACE synthetic inhibitory peptides available for clinical use include captopril, enalapril and lisinopril. Currently, developing inhibitory peptides from natural food sources, or phenolic compounds from plant sources to inhibit ACE is underway. ACE plays a critical role in fertilization by releasing the proteins anchored to glycosylphosphatidylinositol (GPI) in sperm membrane.
Other Notes: One unit will produce 1.0 μmole of hippuric acid from Hippuryl-His-Leu per min in 50 mM HEPES and 300 mM NaCl at pH 8.3 at 37 °C.
Symbol GHS08  GHS08
Signal word Danger
Hazard statements H334
Precautionary statements P261 - P284 - P501
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
activity specific activity: ≥2.0 units/mg protein (modified Warburg-Christian)
Storage Temp. −20°C
Enzyme Commission (EC) Number 3.4.15.1   ( BRENDA  | IUBMB  )
UNSPSC 12352204

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Tariffs & Effects on Pricing

Tariff note: As we navigate the current environment of tariff surcharges and mid-year manufacturer price increases, we want to keep you informed. While we have avoided making specific decisions thus far, we anticipate that we will be forced to implement a cost adjustment policy to offset the fees we have already been absorbing. We are committed to transparency and moderation in this process.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top