Acetylcholine chloride
SIGMA/A6625 - ≥99% (TLC)
Synonym: ACh
CAS Number: 60-31-1
Empirical Formula (Hill Notation): C7H16ClNO2
Molecular Weight: 181.66
EC Number: 200-468-8
MDL Number: MFCD00011698
Linear Formula: (CH3)3N+CH2CH2OCOCH3Cl-
Product Type: Chemical
FT-IR Spectra for ACh.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A6625-500G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A6625-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A6625-25G
| assay | ≥99% (TLC) |
| InChI | 1S/C7H16NO2.ClH/c1-7(9)10 |
| InChI key | JUGOREOARAHOCO-UHFFFAOYSA |
| mp | 146-150 °C (lit.) |
| Quality Level | 200  |
| SMILES string | [Cl-].CC(=O)OCC[N+](C)(C) |
| solubility | H2O: 100 mg/mL |
| Application: | Acetylcholine chloride has been used: • as an agent to trigger sudomotor axon reflex response during autonomic test • to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats • as a substrate for acetylcholinesterase • to stimulate after discharge in Aplysia bag cell neurons |
| Biochem/physiol Actions: | Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6. |
| Biochem/physiol Actions: | Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions. |
| Disclaimer: | Very hygroscopic |
| General description: | Acetylcholine is a neurotransmitter released at nerve endings in both the central and peripheral nervous systems. Acetylcholine chloride (C7H16ClNO2) is a stable cholinergic agonist with muscarinic and nicotinic actions. It is available as white or off-white hygroscopic crystals, or as a crystalline powder. Acetylcholine chloride is hygroscopic in nature and is highly soluble in water, alcohol, propylene glycol and chloroform. |
| Packaging: | 10 mg in glass bottle |
| Packaging: | 25, 100, 500 g in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (TLC) |
| mp | 146-150 °C (lit.) |
| UNSPSC | 51151535 |