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Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt

SIGMA/A3227 - ≥98% (HPLC), lyophilized powder

Synonym: AYPGKF-NH2; PAR4-AP

CAS Number: 1228078-65-6
Empirical Formula (Hill Notation): C34H48N8O7 · xC2HF3O2
Molecular Weight: 680.79 (free base basis)
MDL Number: MFCD04974484
Linear Formula: C34H48N8O7 · xC2HF3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-A3227-1MG 1 mg
 $211.00
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assay ≥98% (HPLC)
color white
form lyophilized powder
InChI 1S/C34H48N8O7.C2HF3O2/c1-21(36)31(46)41-27(19-23-12-14-24(43)15-13-23)34(49)42-17-7-11-28(42)33(48)38-20-29(44)39-25(10-5-6-16-35)32(47)40-26(30(37)45)18-22-8-3-2-4-9-22;3-2(4,5)1(6)7/h2-4,8-9,12-15,21,25-28,43H,5-7,10-11,16-20,35-36H2,1H3,(H2,37,45)(H,38,48)(H,39,44)(H,40,47)(H,41,46);(H,6,7)/t21-,25-,26-,27-,28-;/m0./s1
InChI key BGPJLFVICWHITH-HKJXYENISA-N
Quality Level 100 
SMILES string OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2CCCC2C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(N)=O
solubility H2O: >10 mg/mL
storage temp. −20°C
Amino Acid Sequence: Ala-Tyr-Pro-Gly-Lys-Phe-NH2
Application: 4-Androsten-11β-ol-3,17-dione has been used in platelet aggregation.
Application: AYPGKF- NH2 may be used for probing PAR4 signaling in culture systems and in platelets.
Biochem/physiol Actions: AYPGK is a ligand for the PAR4 receptor; binding results in activation of PAR4. AYPGK stimulates platelet aggregation in vitro (EC50 =15 μM) via PAR4. In human platelets treated with the PAR4 agonist, AYPGKF stimulates the production of thromboxane, a potent agent for platelet-aggregation. Additionally, AYPGKF mediates the thrombin-induced release of endostatin from rat platelets.
General description: Ala-Tyr-Pro-Gly-Lys-Phe-NH2 (AYPGKF- NH2) is a selective, specific proteinase-activated receptor 4 (PAR4) agonist peptide. PAR4 is a G-protein-coupled receptor that is expressed on the surface of human platelets and is involved in the thrombin signaling pathway. Cleavage of PAR4 by the protease thrombin stimulates the receptor and results in signaling of platelet aggregation.
Packaging: 1 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352202

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