N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide

SIGMA/A2559 - ≥97% (HPLC), powder

Synonym: Ac-DEVD-pNA

CAS Number: 189950-66-1
Empirical Formula (Hill Notation): C₂₆H₃₄N₆O₁₃
Molecular Weight: 638.58
MDL Number: MFCD00792707
Linear Formula: C₂₆H₃₄N₆O₁₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A2559-5MG	5 mg	$224.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white
form	powder
InChI	1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)/t16-,17-,18-,22-/m0/s1
InChI key	GGXRLUDNGFFUKI-ORGXJRBJSA-N
Quality Level	100
SMILES string	CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O
storage temp.	−20°C

Amino Acid Sequence:	NAc-Asp-Glu-Val-Asp-pNA
Application:	N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines.
Biochem/physiol Actions:	Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
Packaging:	5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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