Synonym: (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide disulfate; Antibiotic BB-K8 sulfate
CAS Number: 39831-55-5
Empirical Formula (Hill Notation): C22H43N5O13 · 2H2SO4
Molecular Weight: 781.76
EC Number: 254-648-6
MDL Number: MFCD00167475
Linear Formula: C22H43N5O13 · 2H2SO4
Product Type: Chemical
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| antibiotic activity spectrum |
Gram-negative bacteria |
| |
mycobacteria |
| biological source |
synthetic |
| color |
white to off-white |
| form |
powder or crystals |
| InChI |
1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1 |
| InChI key |
FXKSEJFHKVNEFI-GCZBSULCSA-N |
| mode of action |
protein synthesis | interferes |
| potency |
674-786 μg per mg (as amikacin base) |
| Quality Level |
200  |
| SMILES string |
OS(O)(=O)=O.OS(O)(=O)=O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O |
| storage temp. |
2-8°C |
| Application: |
Amikacin is an aminoglycoside antibiotic commonly used in the treatment of drug-resistant mycobacteria . It is used to study organism-directed delivery of antibiotics as well as drug resistance . |
| Biochem/physiol Actions: |
Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading. |
| General description: |
Chemical structure: aminoglycoside |
| Other Notes: |
Keep container tightly closed in a dry and well-ventilated place. |
| Packaging: |
Bottomless glass bottle. Contents are inside inserted fused cone. |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 2 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Storage Temp. |
2-8°C |
| UNSPSC |
51281632 |